Canine Cerebral Metabolism and Blood Flow during Hypoxemia and Normoxic Recovery from Hypoxemia

Hypoxemia and coronary blood flow.

Hypoxemia, oxygen content, and the regulation of cerebral blood flow.

This review highlights the influence of oxygen (O2) availability on cerebral blood flow (CBF). Evidence for reductions in O2 content (CaO2 ) rather than arterial O2 tension (PaO2 ) as the chief regulator of cerebral vasodilation, with deoxyhemoglobin as the primary O2 sensor and upstream response effector, is discussed. We review in vitro and in vivo data to summarize the molecular mechanisms u...

Effects of gamma-hydroxybutrate and gamma-butyrolactone on cerebral energy metabolism during exposure and recovery from hypoxemia-oligemia.

Cerebral hypoxia-oligemia was produced by lowering of the arterial PO2 to 30 mm Hg and by right common carotid artery occlusion in rats who were pretreated with intravenous Krebs' solution, gamma-hydroxybutyrate (GHB) (500 mg/kg) or gamma-butyrolactone (GBL) (300 mg/kg). At 0.5 h exposure the right cerebral hemisphere of animals receiving Krebs', GHB or GBL showed equivalent decreases of ATP an...

Effects of Gamma-Hydroxybutyrate and Gamma-Butyrolactone on Cerebral Energy Metabolism During Exposure and Recovery From Hypoxemia-Oligemia

Cerebral hypoxla-ollgemia was produced by lowering of the arterial Po, to 30 mm Hg and by right common carotid artery occlusion in rats who were pretreated with intravenous Krebs' solution, gammahydroxybutyrate (GHB) (500 mg/kg) or gamma-butyrolactone (GBL) (300 mg/kg). At 0.5 h exposure the right cerebral hemisphere of animal* receiving Krebs', GHB or GBL showed equivalent decreases of ATP and...

Hypoxemia

تنفس یکی از اساسی ترین نیازهای انسان است که در صورت عدم تأمین این نیاز، حیات انسان چند دقیقه ای بیشتر ادامه نخواهد یافت. اهمیت این فعالیت حیاتی از تأثیر آن بر تغذیه سلولها به عنوان کوچکترین واحد سازنده بدن انسان نشأت می گیرد، زیرا اکسیژن یکی از مواد ضروری برای سلولها می باشد و کسب این ماده حیاتی فقط از طریق تنفس مناسب و راحت امکان پذیر است .